Peer victimisation and conflict resolution among adolescent girls in a single-sex South Australian school.

This study investigated the peer victimisation and conflict resolution experiences of adolescent girls attending a single-sex school. A modified version of the Direct and Indirect Aggression Scales and conflict resolution scales, drawn particularly from the work of Feldman and Gowen, were administered to 325 students in Years 8 to 11. Girls in all year levels experienced more indirect and verbal than physical victimisation, and older girls were subject to more indirect and verbally aggressive behaviours than younger girls. Non-victims used less overt anger and avoidance than victims. Collectively, the girls used more compromise, avoidance, social support and obliging than overt anger. The results advance our understanding of the behaviours of adolescent girls in conflict with each other in a single-sex setting. [Author abstract, ed

Nain, Mam and Me: Historical artefacts as prompts for reminiscence, reflection and conversation about feeding babies. A qualitative development study

Historical artefacts can act as distancing objects, encouraging neutral discussion around sensitive topics that involve personal decision-making. Infant feeding is an example of a sensitive topic where strong emotions associated with infrequently shared experiences often underlie present beliefs and values. An exhibition of historical artefacts designed to generate discussion around the topic of infant feeding was piloted at the Welsh National Eisteddfod 2015 as part of a qualitative development study. The study indicated that the exhibition was perceived as a safe space for discussion regardless of prior beliefs and experience, and that artefacts acted as effective prompts for reminiscence and reflection. Follow-up interviews identified areas of intergenerational change that impact on intergenerational support – changing hospital practices, expert advice and attitudes towards breastfeeding in public places. The exhibition indicated the potential of historical artefacts to facilitate intra- and intergenerational conversation around sensitive public health topics

Effects of memory load and distraction on performance and event-related slow potentials in a visuospatial working memory task

Brain electrical activity related to working memory was recorded at 15 scalp electrodes during a visuospatial delayed response task. Participants (N = 18) touched the remembered position of a target on a computer screen after either a 1 or 8 sec delay. These memory trials were compared to sensory trials in which the target remained present throughout the delay and response periods. Distracter stimuli identical to the target were briefly presented during the delay on 30% of trials. Responses were less accurate in memory than sensory trials, especially after the long delay. During the delay slow potentials developed that were significantly more negative in memory than sensory trials. The difference between memory and sensory trials was greater at anterior than posterior electrodes. On trials with distracters, the slow potentials generated by memory trials showed further enhancement of negativity whereas there were minimal effects on accuracy of performance. The results provide evidence that engagement of visuospatial working memory generates slow wave negativity with a timing and distribution consistent with frontal activation. Enhanced brain activity associated with working memory is required to maintain performance in the presence of distraction. © 1997 by the Massachusetts Institute of Technolog

Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation

Purpose – Involvement of parents/carers may increase effectiveness of primary school-based alcohol-misuse prevention projects through strengthening family-based protective factors, but rates of parental engagement are typically low. This paper reports findings from an exploratory trial of a school-based prevention intervention – Kids, Adults Together (KAT), based on the Social Development Model, which aimed to promote pro-social family communication in order to prevent alcohol misuse, and incorporated strategies to engage parents/carers. The purpose of this paper is to assess the feasibility and value of conducting an effectiveness trial of KAT. Design/methodology/approach – The study was a parallel-group cluster randomised exploratory trial with an embedded process evaluation. The study took place in south Wales, UK, and involved nine primary schools, 367 pupils in Years 5/6 (aged 9-11 years) and their parents/carers and teachers. Questionnaires were completed by pupils at baseline and four month follow-up, and by parents at six month follow-up. Findings – Overall KAT was delivered with good fidelity, but two of five intervention schools withdrew from the study without completing implementation. In total, 50 per cent of eligible parents participated in the intervention, and KAT had good acceptability among pupils, parents and teachers. However, a number of “progression to effectiveness trial” criteria were not met. Intermediate outcomes on family communication (hypothesised to prevent alcohol misuse) showed insufficient evidence of an intervention effect. Difficulties were encountered in identifying age appropriate outcome measures for primary school-age children, particularly in relation to family communication processes. The study was unable to find comprehensive methodological guidance on exploratory trials. Research limitations/implications – It would not be appropriate to conduct an effectiveness trial as key progression criteria relating to intervention and trial feasibility were not met. There is a need for new measures of family communication which are suitable for primary school-age children, and more guidance on the design and conduct of exploratory/feasibility trials. Originality/value – KAT achieved high rates of parental involvement, and its theoretical framework and processes could be adapted by other interventions which experience difficulties with recruitment of parents/carers

Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression

Purpose: To understand the role of hypoxia in prostate tumor progression and to evaluate the ability of the novel unidirectional hypoxia-activated prodrug OCT1002 to enhance the antitumor effect of bicalutamide. Experimental Design: The effect of OCT1002 on prostate cancer cells (LNCaP, 22Rv1, and PC3) was measured in normoxia and hypoxia in vitro. In vivo, tumor growth and lung metastases were measured in mice treated with bicalutamide, OCT1002, or a combination. Dorsal skin fold chambers were used to image tumor vasculature in vivo. Longitudinal gene expression changes in tumors were analyzed using PCR. Results: Reduction of OCT1002 to its active form (OCT1001) decreased prostate cancer cell viability. In LNCaP-luc spheroids, OCT1002 caused increased apoptosis and decreased clonogenicity. In vivo, treatment with OCT1002 alone, or with bicalutamide, showed significantly greater tumor growth control and reduced lung metastases compared with controls. Reestablishment of the tumor microvasculature following bicalutamide-induced vascular collapse is inhibited by OCT1002. Significantly, the upregulation of RUNX2 and its targets caused by bicalutamide alone was blocked by OCT1002. Conclusions: OCT1002 selectively targets hypoxic tumor cells and enhances the antitumor efficacy of bicalutamide. Furthermore, bicalutamide caused changes in gene expression, which indicated progression to a more malignant genotype; OCT1002 blocked these effects, emphasizing that more attention should be attached to understanding genetic changes that may occur during treatment. Early targeting of hypoxic cells with OCT1002 can provide a means of inhibiting prostate tumor growth and malignant progression. This is of importance for the design and refinement of existing androgen-deprivation regimens in the clinic

Consumption of a High Quantity and a Wide Variety of Vegetables Are Predicted by Different Food Choice Motives in Older Adults from France, Italy and the UK.

BACKGROUND: Consumption of a high quantity and wide variety of vegetables is currently recommended for health. Dietary variety can be low, however, particularly for older adults. This study investigated the affective factors associated with the quantity and variety of vegetables consumed by older adults in France, Italy and the UK. METHODS: Adults aged 65 years plus completed questionnaires on self-reported vegetable intake (quantity and variety), liking for vegetables, attitudes towards intake, and demographic variables. RESULTS: In 497 older adults (France, n = 187, Italy, n = 152, UK, n = 158), higher quantities of vegetables consumed were associated with a higher age, affluence score and liking for vegetables, and a lower importance in consumption of familiarity (smallest β = 0.11, p = 0.03). Greater variety was associated with a higher liking and importance of health benefits, and a lower importance of familiarity (smallest β = -0.11, p < 0.01). Higher quantity and variety combined (quantity × variety) was associated with a higher age, liking and importance of health benefits, and a lower importance of familiarity (smallest β = 0.14, p = 0.02). Country-specific effects were also found (smallest β = 0.20, p < 0.01). CONCLUSIONS: These findings demonstrate a role for liking and a lower concern for eating familiar foods in vegetable consumption, and a particular role for concern for health benefits in the consumption of a greater variety of vegetables

Asymmetrical representation of body orientation

The perceived orientation of objects, gravity, and the body are biased to the left. Whether this leftward bias is attributable to biases in sensing or processing vestibular, visual, and body sense cues has never been assessed directly. The orientation in which characters are most easily recognized-the perceived upright (PU)-can be well predicted from a weighted vector sum of these sensory cues. A simple form of this model assumes that the directions of the contributing inputs are coded accurately and as a consequence participants tilted leftor right-side-down relative to gravity should exhibit mirror symmetric patterns of responses. If a left/right asymmetry were present then varying these sensory cues could be used to assess in which sensory modality or modalities a PU bias may have arisen. Participants completed the Oriented Character Recognition Test (OCHART) while manipulating body posture and visual orientation cues relative to gravity. The response patterns showed systematic differences depending on which side they were tilted. An asymmetry of the PU was found to be best modeled by adding a leftward bias of 5.68 to the perceived orientation of the body relative to its actual orientation relative to the head. The asymmetry in the effect of body orientation is reminiscent of the body-defined left-leaning asymmetry in the perceived direction of light coming from above and reports that people tend to adopt a right-leaning posture

The Upper Respiratory Tract as a Microbial Source for Pulmonary Infections in Cystic Fibrosis. Parallels from Island Biogeography

A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical microbiology and could reframe the interpretation of recent studies comparing communities from lung explant samples, sputum samples, and oropharyngeal swabs. We propose an island biogeography model of the microbial communities inhabiting different niches in human airways. Island biogeography as applied to communities separated by time and space is a useful parallel for exploring microbial colonization of healthy and diseased lungs, with the potential to inform our understanding of microbial community dynamics and the relevance of microbes detected in different sample types. In this perspective, we focus on the intermixed microbial communities inhabiting different regions of the airways of patients with cystic fibrosis

Comparison of SMOS and SMAP Soil Moisture Retrieval Approaches Using Tower-based Radiometer Data over a Vineyard Field

The objective of this study was to compare several approaches to soil moisture (SM) retrieval using L-band microwave radiometry. The comparison was based on a brightness temperature (TB) data set acquired since 2010 by the L-band radiometer ELBARA-II over a vineyard field at the Valencia Anchor Station (VAS) site. ELBARA-II, provided by the European Space Agency (ESA) within the scientific program of the SMOS (Soil Moisture and Ocean Salinity) mission, measures multiangular TB data at horizontal and vertical polarization for a range of incidence angles (30-60). Based on a three year data set (2010-2012), several SM retrieval approaches developed for spaceborne missions including AMSR-E (Advanced Microwave Scanning Radiometer for EOS), SMAP (Soil Moisture Active Passive) and SMOS were compared. The approaches include: the Single Channel Algorithm (SCA) for horizontal (SCA-H) and vertical (SCA-V) polarizations, the Dual Channel Algorithm (DCA), the Land Parameter Retrieval Model (LPRM) and two simplified approaches based on statistical regressions (referred to as 'Mattar' and 'Saleh'). Time series of vegetation indices required for three of the algorithms (SCA-H, SCA-V and Mattar) were obtained from MODIS observations. The SM retrievals were evaluated against reference SM values estimated from a multiangular 2-Parameter inversion approach. The results obtained with the current base line algorithms developed for SMAP (SCA-H and -V) are in very good agreement with the reference SM data set derived from the multi-angular observations (R2 around 0.90, RMSE varying between 0.035 and 0.056 m3m3 for several retrieval configurations). This result showed that, provided the relationship between vegetation optical depth and a remotely-sensed vegetation index can be calibrated, the SCA algorithms can provide results very close to those obtained from multi-angular observations in this study area. The approaches based on statistical regressions provided similar results and the best accuracy was obtained with the Saleh methods based on either bi-angular or bipolarization observations (R2 around 0.93, RMSE around 0.035 m3m3). The LPRM and DCA algorithms were found to be slightly less successful in retrieving the 'reference' SM time series (R2 around 0.75, RMSE around 0.055 m3m3). However, the two above approaches have the great advantage of not requiring any model calibrations previous to the SM retrievals